Krista H Vandenborne

Krista H Vandenborne

Chair

Department: HP-PHYSICAL THERAPY
Business Phone: (352) 273-6085
Business Email: kvandenb@phhp.ufl.edu

About Krista H Vandenborne

Dr. Krista Vandenborne’s research has focused on the implementation of magnetic resonance imaging (MRI) and spectroscopy (MRS) to characterize skeletal muscle in patients. Her laboratory has applied magnetic resonance to the study of skeletal muscle in numerous animal models and a variety of patient populations. Over the last ten years, she has been leading the efforts at the University of Florida to develop a strong translational research program dedicated to the development and validation of MR imaging biomarkers for muscular dystrophy. She serves as the current Director of this project, known as ImagingDMD, which is focused on the development and validation of MRI/MRS biomarkers in Duchenne Muscular Dystrophy. ImagingDMD has collected longitudinal MR images, functional data, clinical endpoints, demographics, and biosamples in ~180 patients with DMD, with 1-9 year followup. The comprehensive natural history data set acquired by ImagingDMD is viewed as one of the field’s most valuable resources for clinical trial design and is utilized by academia, industry and governmental organizations modeling disease trajectory.

Publications

2017 Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology
2014 Journal of Musculoskeletal & Neuronal Interactions
2014 Journals of Gerontology Series A-Biological Sciences and Medical Sciences
2013 International Journal of Computer Assisted Radiology and Surgery
2010 American Journal of Physiology-Endocrinology and Metabolism
2007 American Journal of Physiology-Endocrinology and Metabolism
2006 Archives of Physical Medicine and Rehabilitation
2003 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2002 American Journal of Physiology-Endocrinology and Metabolism
2001 American Journal of Orthodontics and Dentofacial Orthopedics
1998 The American journal of medicine
1997 Magnetic Resonance Materials in Physics Biology and Medicine
1991 Proceedings of the National Academy of Sciences

Grants

Aug 2020 ACTIVE
Development of MRI, Alternative Splicing, and Functional Abilities as Biomarkers in Myotonic Dystrophy Type 1
NATL INST OF HLTH NIAMS ·
Sep 2019 – Aug 2020
Rehabilitation Research Career Development Program
UNIVERSITY OF TEXAS MEDICAL BRANCH · Principal Investigator
Jun 2019 – Jun 2022
Data Transfer Agreement between iDMD and Sarepta Therapeutics, Inc. to share iDMD Natural History data.
SAREPTA THERAPEUTICS · Principal Investigator
Jun 2019 – Sep 2019
FibroGen DUA
FIBROGEN INC · Principal Investigator
May 2019 ACTIVE
Interdisciplinary Training in Neuromuscular Plasticity and Rehabilitation
NATL INST OF HLTH NICHD ·
Apr 2019 – Apr 2023
Wave Life Sciences Data Transfer Agreement
WAVE LIFE SCIENCES · Principal Investigator
Sep 2018 – Aug 2019
Rehabilitation Research Career Development Program
UNIVERSITY OF TEXAS MEDICAL BRANCH · Principal Investigator
Apr 2018 – Apr 2021
Collaborative study between iDMD and Trajectory Analysis Project Collaboration ("cTAP").
ANALYSIS GROUP · Principal Investigator
Nov 2017 – Jul 2018
Summit-iDMD Natural History Data Transfer Agreement
SUMMIT (OXFORD) LTD · Principal Investigator
Nov 2017 – Jul 2018
Summit C11006 Expansion Site Feasibility
SUMMIT (OXFORD) LTD · Principal Investigator
Oct 2017 – Feb 2020
A randomised, double blind, placebo controlled study to evaluate the micro-macroscopic effects on muscles, the safety and tolerability, and the efficacy of givinostat in patients with Becker Muscular Dystrophy
ITALFARMACO S P A · Principal Investigator
Sep 2017 – Aug 2018
Rehabilitation Research Career Development Program
UNIVERSITY OF TEXAS MEDICAL BRANCH · Principal Investigator
Nov 2016 – Nov 2019
Imaging DMD DUA for C-Path
CRITICAL PATH INSTITUTE · Principal Investigator
Sep 2016 ACTIVE
MR Assessment of Bioenergetics and Microvascular Function in Dystrophic Muscle
NATL INST OF HLTH NIAMS ·
Jul 2016 – Dec 2020
ImagingDMD for Givinostat Phase 3 Clinical Trial
ITALFARMACO S P A · Principal Investigator
Jun 2016 – Aug 2018
Development of Magnetic Resonance Imaging as an Endpoint in Myotonic Dystrophy Type 1
WYCK FOUNDATION ·
Mar 2016 – Mar 2020
protocol CAT-1004-201-moveDMD part B
CATABASIS PHARMACEUTICALS · Principal Investigator
Feb 2016 – Aug 2018
A phase 2 clinical study to assess the activity and
SUMMIT (OXFORD) LTD · Principal Investigator
Dec 2015 – Dec 2016
Data Transfer Agreement
ITALFARMACO S P A · Principal Investigator
Oct 2015 – Oct 2020
Data Transfer Agreement
CATABASIS PHARMACEUTICALS · Principal Investigator
Oct 2015 – Mar 2019
OneFlorida Clinical Research Consortium Phase II
PATIENT-CENTERED OUTCOMES RES INST · Project Manager
Sep 2015 – Sep 2020
Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy
NATL INST OF HLTH NIAMS · Principal Investigator
Sep 2015 – Aug 2020
DSR Match support-Magnetic Resonance imaging and biomarkers for muscular distrophy
UF DIV OF SPONSORED RES MATCHING FUNDS · Principal Investigator
Sep 2015 – Aug 2016
VBP15, an Innovative Steroid-like Intervention on DMD: VISION DMD
UNIV OF PITTSBURGH · Principal Investigator
Aug 2015 – Aug 2016
Idera Pharmaceuticals Data Use Agreement
IDERA PHARMACEUTICALS · Principal Investigator
Aug 2015 ACTIVE
Failed Regeneration in the Muscular Dystrophies: Inflammation, Fibrosis and Fat
NATL INST OF HLTH NIAMS ·
Aug 2015 – Jul 2018
MRI, MRS, and functional characterization of the arm in DMD
MUSCULAR DYSTROPHY ASSO · Principal Investigator
Jul 2015 – Jul 2016
summit therapeutics DUA
SUMMIT THERAPEUTICS · Principal Investigator
Jun 2015 – Mar 2016
Data Use agreement Pfizer-ImagingDMD
PFIZER INC · Principal Investigator
Jun 2015 – Jun 2016
Sarepta data transfer agreement
SAREPTA THERAPEUTICS · Principal Investigator
May 2015 – May 2023
A Phase 1/2 STUDY OF CAT-1004 IN PEDIATRIC PATIENTS with Duchenne Muscular Dystrophy
CATABASIS PHARMACEUTICALS · Principal Investigator
May 2015 – May 2018
A PHASE 2 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTIPLE ASCENDING DOSE STUDY TO EVALUATE THE SAFETY, EFFICACY, PHARMACOKINETICS AND PHARMACODYNAMICS OF PF-06252616 IN AMBULATORY BOYS WITH DUCHENNE MUSCULAR DYSTROPHY
PFIZER INC · Project Manager
Apr 2015 – Jun 2017
catabasis study
CATABASIS PHARMACEUTICALS · Principal Investigator
Mar 2015 – Jun 2019
MR Imaging in Eteplirsen Study 4658-203
SAREPTA THERAPEUTICS · Principal Investigator
Sep 2014 – Jun 2018
Development of a Strength Training Protocol in Duchenne
NATL INST OF HLTH NIAMS · Project Manager
May 2014 – Apr 2019
Interdisciplinary Training in Rehabilitation and Neuromuscular Plasticity
NATL INST OF HLTH NICHD ·
May 2014 – Apr 2019
DSR Match
UF DIV OF SPONSORED RES MATCHING FUNDS · Project Manager
Dec 2013 – Jul 2016
Eli Lilly Contract
ELI LILLY AND CO · Principal Investigator
Sep 2013 – Aug 2018
The relationship between genomic variants and MRI/MRS…
NATL INST OF HLTH NIAMS · Project Manager
Sep 2013 – Aug 2017
Rehabilitation Research Career Development Program
UNIVERSITY OF TEXAS MEDICAL BRANCH · Principal Investigator
Sep 2012 – Sep 2017
MD110050 Optical Imaging of Dystrophic and Damaged Muscle
US DEPT OF DEFENSE · Project Manager
Sep 2011 – Mar 2016
FL Trauma Rehab Center for Returning Military Personnel
US DEPT OF DEFENSE · Project Manager
Jul 2010 – Apr 2016
Matching Funds – MRI and Biomarkers for Muscular Dystrop
UF DIV OF SPONSORED RES MATCHING FUNDS · Principal Investigator
Jan 2008 – Aug 2017
K12 Rehabilitation Research Career Development Program
UF DIV OF SPONSORED RES MATCHING FUNDS · Principal Investigator
Jul 2007 – Aug 2016
Clinical and Translational Science Institute
UF RESEARCH FOU · Project Manager

Contact Details

Phones:
Business:
(352) 273-6085
Emails: