Barbara K Smith,
Assistant Professor
Teaching Profile
Courses Taught
2013-2024
PHT6302C Principles of Disease
2012-2022
HSC4970 Public Health and Health Professions Senior Honors Thesis
2020
PHT6609 Evidence Base Pract 3
2018
RSD6930 Special Topics in Rehabilitation Science
2016
HSC4905 Individual Study
2015,2023
PHT6935C Seminar
2011-2014
PHT6207C Basic Clinic Skills 2
2021-2023
RSD6910 Supervised Research
2022
PHT6206C Basic Clinic Skills 1
2023-2024
RSD7979 Advanced Research
2024
PHT6930 Emerging Practice in Physical Therapy
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-3255-7036
Publications
2024
Effects of gene replacement therapy with resamirigene bilparvovec (AT132) on skeletal muscle pathology in X-linked myotubular myopathy: results from a substudy of the ASPIRO open-label clinical trial.
EBioMedicine.
99
[DOI] 10.1016/j.ebiom.2023.104894.
[PMID] 38086156.
2024
Longitudinal changes of swallowing safety and efficiency in infants with spinal muscular atrophy who received disease modifying therapies
Pediatric Pulmonology.
[DOI] 10.1002/ppul.26919.
2023
Diaphragm pacing and independent breathing in individuals with severe Pompe disease.
Frontiers in rehabilitation sciences.
4
[DOI] 10.3389/fresc.2023.1184031.
[PMID] 37583873.
2023
Intraoperative Hemi-Diaphragm Electrical Stimulation Demonstrates Attenuated Mitochondrial Function without Change in Oxidative Stress in Cardiothoracic Surgery Patients.
Antioxidants (Basel, Switzerland).
12(5)
[DOI] 10.3390/antiox12051009.
[PMID] 37237876.
2023
On “Clinical and Research Readiness for Spinal Muscular Atrophy: The Time Is Now for Knowledge Translation.” Krosschell KJ, Young SD, Peterson I, et al. Phys Ther. 2022;102:pzac108. https://doi.org/10.1093/Ptj/pzac108
Physical Therapy.
103(3)
[DOI] 10.1093/ptj/pzad008.
2023
Polysomnography findings in children with spinal muscular atrophy after onasemnogene-abeparvovec.
Sleep medicine.
101:234-237
[DOI] 10.1016/j.sleep.2022.11.006.
[PMID] 36442421.
2023
Predictors of Peak Expiratory Cough Flow in Individuals with Amyotrophic Lateral Sclerosis.
Dysphagia.
38(2):719-725
[DOI] 10.1007/s00455-022-10503-8.
[PMID] 35931882.
2023
Respiratory therapies for Amyotrophic Lateral Sclerosis: A state of the art review
Chronic Respiratory Disease.
20
[DOI] 10.1177/14799731231175915.
[PMID] 37219417.
2023
Safety and efficacy of gene replacement therapy for X-linked myotubular myopathy (ASPIRO): a multinational, open-label, dose-escalation trial.
The Lancet. Neurology.
22(12):1125-1139
[DOI] 10.1016/S1474-4422(23)00313-7.
[PMID] 37977713.
2022
Acute intermittent hypoxia and respiratory muscle recruitment in people with amyotrophic lateral sclerosis: A preliminary study.
Experimental neurology.
347
[DOI] 10.1016/j.expneurol.2021.113890.
[PMID] 34624328.
2022
Characterizing Expiratory Respiratory Muscle Degeneration in Duchenne Muscular Dystrophy Using MRI.
Chest.
161(3):753-763
[DOI] 10.1016/j.chest.2021.08.078.
[PMID] 34536384.
2022
Effect of Test Interface on Respiratory Muscle Activity and Pulmonary Function During Respiratory Testing in Healthy Adults: A Pilot Study.
Cardiopulmonary physical therapy journal.
33(2):87-95
[DOI] 10.1097/cpt.0000000000000183.
[PMID] 36148286.
2022
Exploring inspiratory occlusion metrics to assess respiratory drive in patients under acute intermittent hypoxia.
Respiratory physiology & neurobiology.
304
[DOI] 10.1016/j.resp.2022.103922.
[PMID] 35680039.
2022
INCEPTUS Natural History, Run-in Study for Gene Replacement Clinical Trial in X-Linked Myotubular Myopathy.
Journal of neuromuscular diseases.
9(4):503-516
[DOI] 10.3233/JND-210781.
[PMID] 35694931.
2021
Case Studies in Neuroscience: Neuropathology and diaphragm dysfunction in ventilatory failure from late-onset Pompe disease
Journal of Neurophysiology.
126(2):351-360
[DOI] 10.1152/jn.00190.2021.
[PMID] 34191636.
2020
Diaphragm remodelling following cervical spinal cord injury: Can intrinsic neural plasticity be harnessed to improve respiratory motor function?
The Journal of physiology.
598(11):2049-2050
[DOI] 10.1113/JP279707.
[PMID] 32266973.
2020
Ultrafast ultrasound responses to twitch stimulation: bridging the gap between non‐volitional and non‐invasive tests of diaphragm contractility
The Journal of Physiology.
598(24):5599-5600
[DOI] 10.1113/jp280863.
2019
Cough Effectiveness and Pulmonary Hygiene Practices in Patients with Pompe Disease
Lung.
197(1):1-8
[DOI] 10.1007/s00408-018-0171-1.
[PMID] 30361764.
2019
Dynamic respiratory muscle function in late-onset Pompe disease
Scientific Reports.
9(1)
[DOI] 10.1038/s41598-019-54314-8.
[PMID] 31831753.
2019
Imaging respiratory muscle quality and function in Duchenne muscular dystrophy.
Journal of neurology.
266(11):2752-2763
[DOI] 10.1007/s00415-019-09481-z.
[PMID] 31350642.
2019
Inspiratory Muscle Training in Patients with Prolonged Mechanical Ventilation: Narrative Review.
Cardiopulmonary physical therapy journal.
30(1):44-50
[DOI] 10.1097/CPT.0000000000000092.
[PMID] 31105474.
2019
Lower Extremity Functional Outcome Measures in Duchenne Muscular Dystrophy-A Delphi Survey.
Journal of neuromuscular diseases.
6(1):75-83
[DOI] 10.3233/JND-180337.
[PMID] 30562905.
2019
Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy.
Annals of translational medicine.
7(13)
[DOI] 10.21037/atm.2019.05.56.
[PMID] 31392202.
2018
Mechanical Ventilation for Duchenne Muscular Dystrophy: Sinner or Saint?
Muscle & nerve.
57(3):353-355
[DOI] 10.1002/mus.25986.
[PMID] 29023941.
2018
Strategies for the Integration of Cough and Swallow to Maintain Airway Protection in Humans.
Lung.
196(5):601-608
[DOI] 10.1007/s00408-018-0133-7.
[PMID] 29926179.
2017
Inspiratory muscle conditioning exercise and diaphragm gene therapy in Pompe disease: Clinical evidence of respiratory plasticity.
Experimental neurology.
287(Pt 2):216-224
[DOI] 10.1016/j.expneurol.2016.07.013.
[PMID] 27453480.
2017
Safety of Intradiaphragmatic Delivery of Adeno-Associated Virus-Mediated Alpha-Glucosidase (rAAV1-CMV-hGAA) Gene Therapy in Children Affected by Pompe Disease.
Human gene therapy. Clinical development.
28(4):208-218
[DOI] 10.1089/humc.2017.146.
[PMID] 29160099.
2017
Systemic AAV8-Mediated Gene Therapy Drives Whole-Body Correction of Myotubular Myopathy in Dogs.
Molecular therapy : the journal of the American Society of Gene Therapy.
25(4):839-854
[DOI] 10.1016/j.ymthe.2017.02.004.
[PMID] 28237839.
2016
Altered activation of the diaphragm in late-onset Pompe disease.
Respiratory physiology & neurobiology.
222:11-5
[DOI] 10.1016/j.resp.2015.11.013.
[PMID] 26612101.
2016
Diaphragm Pacing as a Rehabilitative Tool for Patients With Pompe Disease Who Are Ventilator-Dependent: Case Series.
Physical therapy.
96(5):696-703
[DOI] 10.2522/ptj.20150122.
[PMID] 26893511.
2016
Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study.
Journal of translational medicine.
14(1)
[PMID] 27784315.
2016
Reply: Respiratory motor function in centronuclear myopathy.
Muscle & nerve.
53(4):660-1
[DOI] 10.1002/mus.24961.
[PMID] 26561983.
2016
Respiratory motor function in individuals with centronuclear myopathies.
Muscle & nerve.
53(2):214-21
[DOI] 10.1002/mus.24899.
[PMID] 26351754.
2015
Altered activation of the tibialis anterior in individuals with Pompe disease: Implications for motor unit dysfunction.
Muscle & nerve.
51(6):877-83
[DOI] 10.1002/mus.24444.
[PMID] 25186912.
2015
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy.
Annals of translational medicine.
3(18)
[DOI] 10.3978/j.issn.2305-5839.2015.10.31.
[PMID] 26605308.
2014
Effect of intermittent phrenic nerve stimulation during cardiothoracic surgery on mitochondrial respiration in the human diaphragm.
Critical care medicine.
42(2):e152-6
[DOI] 10.1097/CCM.0b013e3182a63fdf.
[PMID] 24126442.
2014
Intrinsic transient tracheal occlusion training and myogenic remodeling of rodent parasternal intercostal fibers.
Journal of rehabilitation research and development.
51(5):841-54
[PMID] 25509059.
2014
Phrenic nerve stimulation increases human diaphragm fiber force after cardiothoracic surgery.
American journal of respiratory and critical care medicine.
190(7):837-9
[DOI] 10.1164/rccm.201405-0993LE.
[PMID] 25271750.
2014
Respiratory assessment in centronuclear myopathies.
Muscle & nerve.
50(3):315-26
[DOI] 10.1002/mus.24249.
[PMID] 24668768.
2014
Transcriptional regulation of myotrophic actions by testosterone and trenbolone on androgen-responsive muscle.
Steroids.
87:59-66
[DOI] 10.1016/j.steroids.2014.05.024.
[PMID] 24928725.
2013
Acid Alpha-Glucosidase Gene Replacement Therapy To the Diaphragm in Ventilator-Dependent Pompe Disease: One-Year Respiratory Motor Outcomes
Molecular Therapy.
21:S23-S24
2013
Adeno-associated virus-mediated gene therapy for metabolic myopathy.
Human gene therapy.
24(11):928-36
[DOI] 10.1089/hum.2013.2514.
[PMID] 24164240.
2013
Clinical Trial Readiness for Gene Replacement To the Diaphragm: Translational Respiratory Endpoints in Ventilator-Dependent Neuromuscular Diseases
Molecular Therapy.
21
2013
Inspiratory muscle strength training in infants with congenital heart disease and prolonged mechanical ventilation: a case report.
Physical therapy.
93(2):229-36
[DOI] 10.2522/ptj.20110348.
[PMID] 22466028.
2013
Mechanical ventilation, diaphragm weakness and weaning: a rehabilitation perspective.
Respiratory physiology & neurobiology.
189(2):377-83
[DOI] 10.1016/j.resp.2013.05.012.
[PMID] 23692928.
2013
Phase I/II trial of adeno-associated virus-mediated alpha-glucosidase gene therapy to the diaphragm for chronic respiratory failure in Pompe disease: initial safety and ventilatory outcomes.
Human gene therapy.
24(6):630-40
[DOI] 10.1089/hum.2012.250.
[PMID] 23570273.
2013
The respiratory neuromuscular system in Pompe disease.
Respiratory physiology & neurobiology.
189(2):241-9
[DOI] 10.1016/j.resp.2013.06.007.
[PMID] 23797185.
2012
Blunted Ventilatory Response To Central Nervous Stimulation in a Canine Model of X-Linked Myotubular Myopathy
Molecular Therapy.
20
2012
Chronic intrinsic transient tracheal occlusion elicits diaphragmatic muscle fiber remodeling in conscious rodents.
PloS one.
7(11)
[DOI] 10.1371/journal.pone.0049264.
[PMID] 23133678.
2012
Clinical Methods of Intramuscular Diaphragm Injections for Gene Therapy
Molecular Therapy.
20:S174-S175
2012
Establishing clinical end points of respiratory function in large animals for clinical translation.
Physical medicine and rehabilitation clinics of North America.
23(1):75-94, xi
[DOI] 10.1016/j.pmr.2011.11.017.
[PMID] 22239876.
2011
Gene expression changes in the human diaphragm after cardiothoracic surgery.
The Journal of thoracic and cardiovascular surgery.
142(5):1214-22, 1222.e1
[DOI] 10.1016/j.jtcvs.2011.02.025.
[PMID] 21463877.
2011
Group-Advantaged Training of Research (Gator): a Metamorphosis of Mentorship
Bioscience.
61(4):301-311
[DOI] 10.1525/bio.2011.61.4.10.
2011
Inspiratory muscle strength training improves weaning outcome in failure to wean patients: a randomized trial.
Critical care (London, England).
15(2)
[DOI] 10.1186/cc10081.
[PMID] 21385346.
2011
Inspiratory muscle training in a child with nemaline myopathy and organ transplantation.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
12(2):e94-8
[DOI] 10.1097/PCC.0b013e3181dde680.
[PMID] 20407395.
2011
Pompe disease gene therapy.
Human molecular genetics.
20(R1):R61-8
[DOI] 10.1093/hmg/ddr174.
[PMID] 21518733.
Grants
Sep 2023
ACTIVE
Inspiratory Muscle Training to Improve Total Joint Arthroplasty Outcomes
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Mar 2022
ACTIVE
Home-based digital exercise training program to improve physical function of older sepsis survivorsHEAL Sepsis Trial
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Jan 2022
ACTIVE
Acute adenosine receptor antagonism to promote breathing plasticity in ALS
Role: Principal Investigator
Funding: AMYOTROPHIC LATERAL SCLEROSIS ASSOC
Sep 2020
ACTIVE
Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Jun 2020
ACTIVE
Augmenting a PostStroke Wellness Program with Respiratory Muscle Training: A Randomized Controlled Trial
Role: Co-Investigator
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
Jul 2017
– May 2022
The effect of intermittent hemidiaphragm stimulation during surgery on mitochondrial function, single fiber contractile force and catabolic pathways in humans
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Sep 2016
– Jan 2019
Diaphragm pacing and rehabilitation in Pompe disease
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
May 2016
– May 2019
A Prospective, Non-Interventional Clinical Assessment Study in X-Linked Myotublar Myopathy (XLMTM) Subjects Aged 3 Years and Younger
Role: Principal Investigator
Funding: PHARM OLAM
via AUDENTES THERAPEUTICS
Sep 2015
– Jul 2021
Phase II Study of AAV9-GAA Gene Transfer in Pompe Disease
Role: Project Manager
Funding: NATL INST OF HLTH NHLBI
Aug 2015
– Jul 2021
Failed Regeneration in the Muscular Dystrophies: Inflammation, Fibrosis and Fat
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Jul 2015
– Jul 2018
Dynamic Respiratory Muscle Function in Late-Onset Pompe Disease
Role: Principal Investigator
Funding: BIOMARIN PHARMACEUTICAL
Jul 2015
– Jun 2019
Respiratory Muscle Function in Untreated X-linked Myotubular Myopathy
Role: Principal Investigator
Funding: AUDENTES THERAPEUTICS
Apr 2015
– Apr 2018
A Study of Respiratory Muscle Strength, including Effort-Independent Measures, in Subjects with Late-Onset Pompe Disease
Role: Principal Investigator
Funding: FORTREA
via BIOMARIN PHARMACEUTICAL
Apr 2015
– Jun 2021
Clinical and Translational Science Institute (CTSI)
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Apr 2015
– Dec 2016
Project Development Planning
Role: Project Manager
Funding: SOLID GT LLC
Mar 2014
– Feb 2017
Response to Diaphragmatic Pacing in Subjects with Pompe Disease
Role: Principal Investigator
Funding: ACID MALTASE DEFICIENCY ASSO
Aug 2013
– Feb 2018
Advanced Gene Therapy for Treatment of Cardiomyopathy and Respiratory Insufficiency in Duchenne Muscular Dystrophy
Role: Project Manager
Funding: US ARMY MED RES ACQUISITION
Aug 2013
– Mar 2016
Phase I/II Trial of Diaphragm Delivery of Recombinant Adeno-Associated Virus Acid Alpha-Glucosidase (rAAV1-CMV-GAA) Gene Vector in Patients with Pompe Disease
Role: Project Manager
Funding: SOCIAL AND SCIENTIFIC SYSTEMS
via NATL INST OF HLTH NHLBI
Education
PhD in Rehabilitation Science
2010
·
University of Florida
MPT, Physical Therapy
1994
·
University of Pittsburgh
Contact Details
Phones:
- Business:
- (352) 294-5315
Emails:
- Business:
- bksmith@phhp.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100154
GAINESVILLE FL 32610 - Business Street:
-
RM 1140
PO Box 100154
HPNP BLDG
GAINESVILLE FL 32610