Gordon S Mitchell

Gordon S Mitchell, Ph.D.

PROF

Department: HP-PHYSICAL THERAPY
Business Phone: (352) 273-6085
Business Email: gsmitche@phhp.ufl.edu

About Gordon S Mitchell

Dr. Mitchell joined the University of Florida in 2015 as a Preeminence Professor of Neuroscience in the Department of Physical Therapy and McKnight Brain Institute. He opened and directs the UF Center for Breathing Research and Therapeutics (BREATHE) and an NIH-funded graduate and postdoctoral training program of the same name. A major focus of BREATHE is to understand and treat impaired breathing and airway defense (swallowing/cough) caused by neuromuscular injury or disease. For the past three decades, Dr. Mitchell pioneered studies of neuroplasticity in the neural system controlling breathing. Areas of active investigation include: cellular and molecular mechanisms of long-lasting motor plasticity triggered by repeated exposure to low oxygen (intermittent hypoxia), the ability to harness that intermittent hypoxia-induced plasticity to treat respiratory and non-respiratory paralysis following spinal injury, mechanisms of spontaneous and induced compensation during motor neuron diseases such as ALS, cell-based strategies to treat breathing deficits, and the impact of systemic inflammation on breathing and its control. Investigations span intracellular, intercellular and physiological systems level mechanisms, and translation to humans with traumatic and neurodegenerative clinical disorders (SCI and ALS). Dr. Mitchell grew up in California where he received his B.S. (biological sciences) and PhD (Developmental and Cell Biology) degrees from the University of California at Irvine. After two years of post-doctoral training at the Max Planck Institute for Experimental Medicine in Gottingen, Germany, he moved to the University of Wisconsin-Madison where he became an Assistant Professor. There, he ascended the ranks to become Professor and Chair of the Department of Comparative Biosciences (17 years) and director of the NIH funded Respiratory Neurobiology Training Program (14 years). He chose to leave the University of Wisconsin for the opportunity to join the University of Florida and create BREATHE (formerly known as the Center for Respiratory Research and Rehabilitation, or CRRR). Dr. Mitchell has been recognized for both his research and teaching accomplishments, including a National Institutes of Health MERIT Award, the Norden Distinguished Teacher Award, the Pfizer Research Award on multiple occasions, the Steenbock Professorship for Behavioral and Neural Science, and distinguished lectureships from the Society for Neuroscience (SFN), American Physiological Society (APS), Association of Chairs of Departments of Physiology (ACDP), and the American Spinal Injury Association (ASIA).

Research Profile

Areas of Interest
  • ALS
  • Intermittent hypoxia
  • Neuroplasticity
  • Respiratory physiology
  • Sleep apnea
  • Spinal cord injury rehabilitation

Publications

2018 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2016 Respiratory Physiology & Neurobiology

Grants

Jan 2020 ACTIVE
Microglial regulation of intermittent hypoxia induced phrenic motor plasticity
NATL INST OF HLTH NHLBI · Principal Investigator
Jul 2019 ACTIVE
Regulation of Intermittent Hypoxia-Induced Respiratory Motor Plasticity
NATL INST OF HLTH NHLBI · Principal Investigator
Jul 2019 ACTIVE
Modulation of Respiratory Motor Plasticity Through Neuron- Microglia Interactions
PARKER B FRANCIS FELLOWSHIP FOU · Mentor
Apr 2019 ACTIVE
Optimizing respiratory plasticity with chronic cervical SCI
NATL INST OF HLTH NHLBI · Principal Investigator
Mar 2019 ACTIVE
The Two Faces of Hypoxia in Alzheimer's Disease
FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER · Principal Investigator
Sep 2018 ACTIVE
Acute Intermittent Hypoxia and Respiratory Strength Training to Improve Breathing Function after SCI
US ARMY MED RES ACQUISITION ·
Aug 2018 ACTIVE
Ampakines and Respiratory Neuroplasticity
NATL INST OF HLTH NHLBI ·
Feb 2018 – Aug 2018
Support for Intermittent Hypoxia Consortium (Conference)
CRAIG H NEILSEN FOU · Principal Investigator
Nov 2017 ACTIVE
Chronic intermittent hypoxia-induced neuroinflammation undermines respiratory motor plasticity after chronic incomplete cervical spinal cord injury
US ARMY MED RES AND MATERIAL COM ·
Jul 2017 ACTIVE
Combinatorial Therapies to Treat Breathing Impairments After Cervical SCI
CRAIG H NEILSEN FOU ·
Apr 2017 ACTIVE
Breathing Research and Therapeutics (BREATHE)
NATL INST OF HLTH NHLBI · Principal Investigator
Sep 2016 ACTIVE
Functional mapping of peripheral and central circuits for airway protection and breathing
NATL INST OF HLTH OD · Project Manager
Jun 2016 – May 2019
Mechanisms of intermittent hypoxia-induced motor recovery in persons with SCI
EMORY UNIV · Principal Investigator
Apr 2016 – Mar 2020
MUSCLE STEM CELLS: NEW ALS GROWTH FACTOR THERAPY AND DISEASEMODEL
UNIV OF WISCONSIN · Principal Investigator
Feb 2016 – Nov 2018
Recovery of breathing and forelimb function after
US ARMY MED RES ACQUISITION · Principal Investigator
Oct 2015 – Oct 2016
Therapeutic Intermittent Hypoxia and Functional Recovery
CRAIG H NEILSEN FOU · Principal Investigator
Jul 2015 – Jan 2020
Respiratory Plasticity and Spinal Cord Injury
NATL INST OF HLTH NHLBI · Principal Investigator
Jan 2015 – Nov 2017
Intermittent Hypoxia-Induced Inflammation Modulates Resp
UNIV OF WISCONSIN · Principal Investigator
Jul 2006 ACTIVE
BRAIN AND SPINAL CORD INJURY RESEARCH
FL DEPT OF HLTH · Project Manager

Contact Details

Phones:
Business:
(352) 273-6085
Emails: