Sarah M Judge

Sarah M Judge,

Research Assistant Professor

Department: HP-PHYSICAL THERAPY
Business Phone: (352) 273-9146
Business Email: smsenf@ufl.edu

Teaching Profile

Courses Taught
2022-2024
PHT6153 Physiology for Pt
2023
PHT6935C Seminar
2024
PHT6157 Pathophysiology for Physical Therapy

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-3974-0247

Areas of Interest
  • Cancer Cachexia
  • Muscle atrophy
  • Skeletal muscle wasting
  • muscle inactivity
  • pre-clinical models

Publications

2024
Heterogeneity of weight loss and transcriptomic signatures in pancreatic ductal adenocarcinoma.
Journal of cachexia, sarcopenia and muscle. 15(1):149-158 [DOI] 10.1002/jcsm.13390. [PMID] 38123146.
2024
Mitochondrial fusion and altered beta-oxidation drive muscle wasting in a Drosophila cachexia model.
EMBO reports. 25(4):1835-1858 [DOI] 10.1038/s44319-024-00102-z. [PMID] 38429578.
2024
Ursolic Acid Induces Beneficial Changes in Skeletal Muscle mRNA Expression and Increases Exercise Participation and Performance in Dogs with Age-Related Muscle Atrophy.
Animals : an open access journal from MDPI. 14(2) [DOI] 10.3390/ani14020186. [PMID] 38254356.
2023
Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth.
Communications biology. 6(1) [DOI] 10.1038/s42003-023-04902-2. [PMID] 37179425.
2023
Blocking muscle wasting via deletion of the muscle-specific E3 ubiquitin ligase MuRF1 impedes pancreatic tumor growth.
Research square. [DOI] 10.21203/rs.3.rs-2524562/v1. [PMID] 36798266.
2023
Low Muscle Mass and Radiodensity Associate with Impaired Pulmonary Function and Respiratory Complications in Patients with Esophageal Cancer.
Journal of the American College of Surgeons. 236(4):677-684 [DOI] 10.1097/XCS.0000000000000535. [PMID] 36728466.
2022
Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy.
The Journal of nutrition. 152(4):926-938 [DOI] 10.1093/jn/nxab440. [PMID] 34958390.
2022
Depleting Ly6G Positive Myeloid Cells Reduces Pancreatic Cancer-Induced Skeletal Muscle Atrophy.
Cells. 11(12) [DOI] 10.3390/cells11121893. [PMID] 35741022.
2022
Osteopenia is associated with wasting in pancreatic adenocarcinoma and predicts survival after surgery.
Cancer medicine. 11(1):50-60 [DOI] 10.1002/cam4.4416. [PMID] 34791809.
2021
FoxP1 is a transcriptional repressor associated with cancer cachexia that induces skeletal muscle wasting and weakness
Journal of Cachexia, Sarcopenia and Muscle. 12(2):421-442 [DOI] 10.1002/jcsm.12666. [PMID] 33527776.
2021
The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer
Cancers. 13(4) [DOI] 10.3390/cancers13040809. [PMID] 33671939.
2020
Distinct cachexia profiles in response to human pancreatic tumours in mouse limb and respiratory muscle
Journal of Cachexia, Sarcopenia and Muscle. 11(3):820-837 [DOI] 10.1002/jcsm.12550. [PMID] 32039571.
2020
MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer.
Cancer research. 80(9):1861-1874 [DOI] 10.1158/0008-5472.CAN-19-1558. [PMID] 32132110.
2020
Nicotine Induces IL-8 Secretion from Pancreatic Cancer Stroma and Worsens Cancer-Induced Cachexia.
Cancers. 12(2) [DOI] 10.3390/cancers12020329. [PMID] 32024069.
2019
IL-8 Released from Human Pancreatic Cancer and Tumor-Associated Stromal Cells Signals through a CXCR2-ERK1/2 Axis to Induce Muscle Atrophy.
Cancers. 11(12) [DOI] 10.3390/cancers11121863. [PMID] 31769424.
2019
Mas Receptor Activation Slows Tumor Growth and Attenuates Muscle Wasting in Cancer.
Cancer research. 79(4):706-719 [DOI] 10.1158/0008-5472.CAN-18-1207. [PMID] 30420474.
2018
Local and Systemic Cytokine Profiling for Pancreatic Ductal Adenocarcinoma to Study Cancer Cachexia in an Era of Precision Medicine.
International journal of molecular sciences. 19(12) [DOI] 10.3390/ijms19123836. [PMID] 30513792.
2018
Skeletal Muscle Fibrosis in Pancreatic Cancer Patients with Respect to Survival.
JNCI cancer spectrum. 2(3) [DOI] 10.1093/jncics/pky043. [PMID] 30637373.
2018
Tumour-derived leukaemia inhibitory factor is a major driver of cancer cachexia and morbidity in C26 tumour-bearing mice.
Journal of cachexia, sarcopenia and muscle. 9(6):1109-1120 [DOI] 10.1002/jcsm.12346. [PMID] 30270531.
2017
A clinically applicable muscular index predicts long-term survival in resectable pancreatic cancer.
Surgery. 161(4):930-938 [DOI] 10.1016/j.surg.2016.09.038. [PMID] 27932030.
2017
Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia.
Oncotarget. 8(1):1177-1189 [DOI] 10.18632/oncotarget.13593. [PMID] 27901481.
2017
Orthotopic Patient-Derived Pancreatic Cancer Xenografts Engraft Into the Pancreatic Parenchyma, Metastasize, and Induce Muscle Wasting to Recapitulate the Human Disease.
Pancreas. 46(6):813-819 [DOI] 10.1097/MPA.0000000000000843. [PMID] 28609371.
2015
Identification of the Acetylation and Ubiquitin-Modified Proteome during the Progression of Skeletal Muscle Atrophy.
PloS one. 10(8) [DOI] 10.1371/journal.pone.0136247. [PMID] 26302492.
2015
Inducible HSP70 is critical in preventing the aggregation and enhancing the processing of PMP22.
ASN neuro. 7(1) [DOI] 10.1177/1759091415569909. [PMID] 25694550.
2014
Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia.
BMC cancer. 14 [DOI] 10.1186/1471-2407-14-997. [PMID] 25539728.
2014
HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy.
Journal of cell science. 127(Pt 7):1441-53 [DOI] 10.1242/jcs.136390. [PMID] 24463822.
2014
Transcriptional regulation of myotrophic actions by testosterone and trenbolone on androgen-responsive muscle.
Steroids. 87:59-66 [DOI] 10.1016/j.steroids.2014.05.024. [PMID] 24928725.
2013
Loss of the inducible Hsp70 delays the inflammatory response to skeletal muscle injury and severely impairs muscle regeneration.
PloS one. 8(4) [DOI] 10.1371/journal.pone.0062687. [PMID] 23626847.
2013
Skeletal muscle heat shock protein 70: diverse functions and therapeutic potential for wasting disorders.
Frontiers in physiology. 4 [DOI] 10.3389/fphys.2013.00330. [PMID] 24273516.
2012
Determination of gene promoter activity in skeletal muscles in vivo.
Methods in molecular biology (Clifton, N.J.). 798:461-72 [DOI] 10.1007/978-1-61779-343-1_27. [PMID] 22130854.
2012
Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(3):987-1000 [DOI] 10.1096/fj.11-189977. [PMID] 22102632.
2011
Inhibition of IkappaB kinase alpha (IKKα) or IKKbeta (IKKβ) plus forkhead box O (Foxo) abolishes skeletal muscle atrophy.
Biochemical and biophysical research communications. 405(3):491-6 [DOI] 10.1016/j.bbrc.2011.01.059. [PMID] 21256828.
2011
p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle.
American journal of physiology. Cell physiology. 300(6):C1490-501 [DOI] 10.1152/ajpcell.00255.2010. [PMID] 21389279.
2010
FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70.
American journal of physiology. Cell physiology. 298(1):C38-45 [DOI] 10.1152/ajpcell.00315.2009. [PMID] 19864323.
2010
Ros-mediated activation of NF-kappaB and Foxo during muscle disuse.
Muscle & nerve. 41(1):110-3 [DOI] 10.1002/mus.21526. [PMID] 19813194.
2009
Hsp27 inhibits IKKbeta-induced NF-kappaB activity and skeletal muscle atrophy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(10):3415-23 [DOI] 10.1096/fj.08-124602. [PMID] 19528257.
2008
Hsp70 overexpression inhibits NF-kappaB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 22(11):3836-45 [DOI] 10.1096/fj.08-110163. [PMID] 18644837.

Grants

Sep 2023 ACTIVE
Matricellular proteins of the CNN family as regulators of tumor-induced cachexia
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
May 2023 ACTIVE
Development of Novel Therapeutics for Cancer Cachexia
Role: Principal Investigator
Funding: EMMYON via NATL INST OF HLTH NCI
Jan 2023 – Jun 2023
Conference Funding for Advances in Skeletal Muscle Biology in Health and Disease Conferences
Role: Principal Investigator
Funding: THE COMPANY OF BIOLOGISTS
Aug 2022 ACTIVE
The Complement System and Cancer Cachexia
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
May 2021 ACTIVE
Ursolic acid as a countermeasure to cancer cachexia
Role: Principal Investigator
Funding: FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE
Sep 2017 – Aug 2023
FoxO signaling and skeletal muscle atrophy
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Apr 2017 – Jun 2021
OoR CTSI Institutional Matching Support
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Mar 2017 – Dec 2020
Initiating Mechanisms of Cancer Cachexia
Role: Co-Investigator
Funding: FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE

Education

PhD in Exercise Physiology/Skeletal Muscle Biology
2012 · University of Florida
Bachelor of Science in Microbiology and Cell Science
2006 · University of Florida

Contact Details

Phones:
Business:
(352) 273-9146
Emails:
Business:
smsenf@ufl.edu
Addresses:
Business Mailing:
PO Box 100154
GAINESVILLE FL 32610
Business Street:
1275 CENTER DR
GAINESVILLE FL 32610